Workers will build a new roundabout on the A6 at the junction with Kettering Road at the top of Clack Hill.
Contractors are being drafted in after a string of serious crashes there over the last few years.
The work is going ahead as a massive new 600-home estate is set to be built on an 88-acre site off Kettering Road.
The Davidsons Homes development will bring at least 1,500 more people into Market Harborough over the next few years – and increase local traffic congestion at the same time.
Drivers will face disruption as the new roundabout will take up to six months to put in.
Temporary traffic lights will be set up overnight for two weeks.
Lane closures are going to be imposed - and motorists won’t be able to turn into Kettering Road from the A6.
The scheme will be carried out by contractors working for Davidsons Homes.
Another new roundabout will also be built on Kettering Road at the entrance to the new estate.